Peter van Gelderen

Contact Information

P. van Gelderen
10 Center Dr.
Bldg. 10, Rm. B1D-726 - MSC 1065
Bethesda, MD 20892-1065
USA
Tel: +1 301 402 1472
Fax: +1 301 480 1981
E-mail: gelderen@nih.gov

Research Interests

My work focuses on development of MRI techniques and methods for brain imaging. This has involved everything from hardware and system design to data analysis, but most of my work has been on imaging acquisition and reconstruction methods, ie.pulse sequence design, implementation and testing. Applications have included imaging of diffusion, perfusion, (relative) blood volume, (relative) iron concentration, high resolution anatomy and fMRI.

Positions

job title Laboratory starting date
Visiting Fellow In Vivo NMR Research Center, BEIP, NCRR, NIH may 1993
Visiting Associate In Vivo NMR Research Center, BEIP, NCRR/ NINDS, NIH october 1996
Visiting Scientist FMIF, NIMH, NIH november 1999
Visiting Scientist AMRI, LFMI, NINDS, NIH december 2000

Education

  • Ir. (= MSc) in Applied Physics, Delft University of Technology, The Netherlands, from September 1984 to November 1988.
    MSc.-thesis on NMR, 'Investigation of selection methods for localized spectroscopy', in the Applied Physics department.
  • Dr. (PhD) in the Technical Sciences, Delft University of Technology, The Netherlands, from January 1989 to February 1993, with Prof. A.F. Mehlkopf, in the Applied Physics department.
    PhD thesis 'Diffusion techniques for in vivo NMR', Delft University Press, 1993. The degree was awarded on May 3, 1993.

Articles

  1. M. Biancardi, M. Fukunaga, P. van Gelderen, S.G. Horovitz, J.A. de Zwart, J.H. Duyn.
    Modulation of spontaneous fMRI activity in human visual cortex by behavior state.
     Neuroimage 2009 45:160-168.
  2. B. Yao, T.Q. Li, P. van Gelderen, K. Shmueli, J.A. de Zwart, J.H. Duyn.
    Suceptibility Contrast in High Field MRI of Human Brain as function of Tissue Iron Content
     Neuroimage 2009 44:1259-1266.
  3. M Biancardi, P. van Gelderen, J.H. Duyn, M. Fukunaga, J.A. de Zwart.
    Making the most of fMRI at 7 T by suppressing spontaneous signal fluctuations.
     Neuroimage 2008 59:939-945.
  4. J.A. de Zwart, P. van Gelderen, J.H. Duyn.
    Reducing correlated noise in fMRI data.
     Magn. Reson Med. 2009 44:448-454.
  5. P. van Gelderen, J.A. de Zwart, J.H. Duyn.
    Pittsfalls of MRI measurement of white matter perfusion based on arterial spin labeling
     Magn. Reson Med. 2008 59:788-795.
  6. M. Fukunaga, S.G. Horovitz, P. van Gelderen, J.A. de Zwart, T.J. Balkin, A.R. Braun, J.H. Duyn.
    Metabolic origin of BOLD signal fluctuations in the absence of stimuli.
     J Cereb Blood Flow Metab. 2008 28:1377-1387
  7. SG Horovitz, M Fukunaga, JA de Zwart, P van Gelderen, SC Fulton, TJ Balkin, JH Duyn.
    Low frequency BOLD fluctuations during resting wakefulness and light sleep: A simultaneous EEG-fMRI study.
     Hum Brain Mapp 2008 29:671-682
  8. K Shmueli, P van Gelderen, JA de Zwart, SG Horovitz, M Fukunaga, JM Jansma, JH Duyn.
    Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal.
     Neuroimage 2007 38:304-320
  9. JH Duyn, P van Gelderen, TQ Li, JA de Zwart, AP Koretsky, M Fukunaga.
    High-field MRI of brain cortical substructure based on signal phase.
     Proc Natl Acad Sci U S A. 2007 104:11796-11801
  10. JM Jansma, NF Ramsey, JA de Zwart, P van Gelderen, JH Duyn
    fMRI study of effort and information processing in a working memory task
     Hum brain App. 2007 28:431-440
  11. P van Gelderen, JA de Zwart, P Starewicz, RS Hinks, JH Duyn
    Real-time shimming to compensate for respiration-induced B0 fluctuations
     Magn. Reson. Med 2007 57:362-368
  12. RH Deckers, P van Gelderen, M Ries, O Barret, JH Duyn, VN Ikonomidou, M Fukunaga, GH Glover, JA de Zwart
    An adaptive filter for suppression of cardiac and respiratory noise in MRI time series data
     Neuroimage 2006 33:1072-1081
  13. M Fukunaga, SG Horovitz, P van Gelderen, JA de Zwart, JM Jansma, VN Ikonomidou, R Chu, RH Deckers, DA Leopold, JH Duyn
    Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages
     Magn Reson Imaging 2006 24:979-992
  14. TQ Li, P van Gelderen, H Merkle, L Talagala, AP Koretsky, JH Duyn
    Extensive heterogeneity in white matter intensity in high-resolution T2*-weighted MRI of the human brain at 7.0 T
     Neuroimage 2006 32:1032-1040
  15. JA de Zwart, P van Gelderen, X Golay, VN Ikonomidou,JH Duyn
    Accelerated parallel imaging for functional imaging of the human brain
     NMR Biomed. 2006 19:342-351
  16. PS Bellgowan, PA Bandettini, P van Gelderen, A Martin, J Bodurka
    Improved BOLD detection in the medial temporal region using parallel imaging and voxel volume reduction.
     Neuroimage 2006 29:1244-1251
  17. JH Duyn, P van Gelderen, L Talagala, A Koretsky, JA de Zwart
    Technological advances in MRI measurement of brain perfusion.
    J Magn Reson Imaging 2005 22:751-753
  18. CW Wu, P van Gelderen, T Hanakawa, Z Yaseen, LG Cohen
    Enduring representational plasticity after somatosensory stimulation.
     Neuroimage 2005 27:872-884
  19. P van Gelderen, CW Wu, JA de Zwart, L Cohen, M Hallett, JH Duyn
    Resolution and reproducibility of BOLD and perfusion functional MRI at 3.0 Tesla.
     Magn Reson Med 2005 54:569-576
  20. VN Ikonomidou, P van Gelderen, JA de Zwart, M Fukunaga, JH Duyn
    Optimizing brain tissue contrast with EPI: a simulated annealing approach.
     Magn Reson Med 2005 54:373-85
  21. JA de Zwart, AC Silva, P van Gelderen, P Kellman, M Fukunaga, R Chu, AP Koretsky, JA Frank, JH Duyn
    Temporal dynamics of the BOLD fMRI impulse response.
     Neuroimage 2005 24:667-677
  22. R Chu, JA de Zwart, P van Gelderen, M Fukunaga, P Kellman, T Holroyd, JH Duyn,
    Hunting for neuronal currents: absence of rapid MRI signal changes during visual-evoked response.
     Neuroimage 2004 23:1059-67
  23. A Ahmad, R Momenan, P van Gelderen, T Moriguchi, RS Greiner, N Salem Jr.,
    Gray and white matter brain volume in aged rats raised on n-3 fatty acid deficient diets.
     Nutr Neurosci 2004 7:13-20
  24. F Fera, MN Yongbi, P van Gelderen, JA Frank, VS Mattay, JH Duyn,
    EPI-BOLD fMRI of human motor cortex at 1.5 T and 3.0 T: sensitivity dependence on echo time and acquisition bandwidth.
     J Magn Reson Imaging 2004 19:19-26
  25. J Bodurka, PJ Ledden, P van Gelderen, R Chu, JA de Zwart, D Morris, JH Duyn,
    Scalable multichannel MRI data acquisition system.
     Magn Reson Med 2004 51:165-71
  26. JA de Zwart, PJ Ledden, P van Gelderen, J Bodurka, R Chu, JH Duyn,
    Signal-to-noise ratio and parallel imaging performance of a 16-channel receive-only brain coil array at 3.0 Tesla.
     Magn Reson Med 2004 51:22-6
  27. M Klarhofer, B Dilharreguy, P van Gelderen, CTW Moonen,
    A PRESTO-SENSE sequence with alternating partial-Fourier encoding for rapid susceptibility-weighted 3D MRI time series.
     Magn Reson Med 2003 50:830-8
  28. T Hanakawa, I Immisch, K Toma, MA Dimyan, P van Gelderen, M Hallett,
    Functional properties of brain areas associated with motor execution and imagery.
     J Neurophysiol 2003 89:989-1002
  29. P Kellman, P van Gelderen, JA de Zwart, JH Duyn,
    Method for functional MRI mapping of nonlinear response.
    Neuroimage 2003, 19: 190-9.
  30. JA de Zwart, P van Gelderen, P Kellman, JH Duyn,
    Application of sensitivity-encoded echo-planar imaging for blood oxygen level-dependent functional brain imaging.
     Magn Reson Med 2002 48:1011-20
  31. EL Barbier, S Marrett, A Danek, A Vortmeyer, P van Gelderen, J Duyn, P Bandettini, J Grafman, AP Koretsky,
    Imaging cortical anatomy by high-resolution MR at 3.0T: detection of the stripe of Gennari in visual area 17.
     Magn Reson Med 2002 48:735-8
  32. A Bertolino, JL Roffman, BK Lipska, P van Gelderen, A Olson, DR Weinberger,
    Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damage.
     Cereb Cortex 2002 12:983-90
  33. JW Bulte, T Douglas, B Witwer, SC Zhang, BK Lewis, P van Gelderen, H Zywicke, ID Duncan, JA Frank,
    Monitoring stem cell therapy in vivo using magnetodendrimers as a new class of cellular MR contrast agents.
     Acad Radiol 2002 9 Suppl 2:S332-5
  34. JA de Zwart, P van Gelderen, P Kellman, JH Duyn,
    Reduction of gradient acoustic noise in MRI using SENSE-EPI.
     Neuroimage 2002 16:1151-5
  35. HA Zywicke, P van Gelderen, JR Connor, JR Burdo, MD Garrick, KG Dolan, JA Frank, JW Bulte,
    Microscopic R2* mapping of reduced brain iron in the Belgrade rat.
     Ann Neurol 2002 52:102-5
  36. JA de Zwart, PJ Ledden, P Kellman, P van Gelderen, JH Duyn,
    Design of a SENSE-optimized high-sensitivity MRI receive coil for brain imaging.
     Magn Reson Med 2002 47:1218-27
  37. JW Bulte, SC Zhang, P van Gelderen, V Herynek, EK Jordan, CH Janssen, ID Duncan, JA Frank,
    Magnetically labeled glial cells as cellular MR contrast agents.
     Acad Radiol 2002 9 Suppl 1:S148-50
  38. JW Bulte, T Douglas, B Witwer, SC Zhang, E Strable, BK Lewis, H Zywicke, B Miller, P van Gelderen, BM Moskowitz, ID Duncan, JA Frank,
    Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells.
     Nat Biotechnol 2001 19:1141-7
  39. I Immisch, D Waldvogel, P van Gelderen, M Hallett,
    The role of the medial wall and its anatomical variations for bimanual antiphase and in-phase movements.
     Neuroimage 2001 14:674-84
  40. JH Duyn, CX Tan, P van Gelderen, MN Yongbi,
    High-sensitivity single-shot perfusion-weighted fMRI.
     Magn Reson Med 2001 46:88-94
  41. D Waldvogel, P van Gelderen, I Immisch, C Pfeiffer, M Hallett,
    The variability of serial fMRI data: correlation between a visual and a motor task.
     Neuroreport 2000 11:3843-7
  42. D Waldvogel, P van Gelderen, W Muellbacher, U Ziemann, I Immisch, M Hallett,
    The relative metabolic demand of inhibition and excitation.
     Nature 2000 406:995-8
  43. P van Gelderen, C Grandin, JR Petrella, CTW Moonen,
    Rapid three-dimensional MR imaging method for tracking a bolus of contrast agent through the brain.
     Radiology 2000 216:603-8
  44. JL Roffman, BK Lipska, A Bertolino, P Van Gelderen, AW Olson, ZZ Khaing, DR Weinberger,
    Local and downstream effects of excitotoxic lesions in the rat medial prefrontal cortex on In vivo 1H-MRS signals.
     Neuropsychopharmacology 2000 22:430-9
  45. W Huang, Z Galdzicki, P van Gelderen, A Balbo, EG Chikhale, MB Schapiro, SI Rapoport,
    Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment.
     Neuroreport 2000 11:445-8
  46. JW Bulte, S Zhang, P van Gelderen, V Herynek, EK Jordan, ID Duncan, JA Frank,
    Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination.
     Proc Natl Acad Sci U S A 1999 96:15256-61
  47. D Waldvogel, P van Gelderen, K Ishii, M Hallett,
    The effect of movement amplitude on activation in functional magnetic resonance imaging studies.
     J Cereb Blood Flow Metab 1999 19:1209-12
  48. D Waldvogel, P van Gelderen, M Hallett,
    Increased iron in the dentate nucleus of patients with Friedrich's ataxia.
     Ann Neurol 1999 46:123-5
  49. JH Callicott, NF Ramsey, K Tallent, A Bertolino, MB Knable, R Coppola, T Goldberg, P van Gelderen, VS Mattay, JA Frank, CTW Moonen, DR Weinberger,
    Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia.
     Neuropsychopharmacology 1998 18:186-96
  50. DP Madio, P van Gelderen, D DesPres, AW Olson, JA de Zwart, TW Fawcett, NJ Holbrook, M Mandel, CTW Moonen,
    On the feasibility of MRI-guided focused ultrasound for local induction of gene expression.
     J Magn Reson Imaging 1998 8:101-4
  51. Y Yang, GH Glover, P van Gelderen, AC Patel, VS Mattay, JA Frank, JH Duyn,
    A comparison of fast MR scan techniques for cerebral activation studies at 1.5 tesla.
     Magn Reson Med 1998 39:61-7
  52. DR Weinberger, V Mattay, J Callicott, K Kotrla, A Santha, P van Gelderen, J Duyn, C Moonen, J Frank,
    fMRI applications in schizophrenia research.
     Neuroimage 1996 4:S118-26
  53. Y Yang, GH Glover, P van Gelderen, VS Mattay, AK Santha, RH Sexton, NF Ramsey, CTW Moonen, DR Weinberger, JA Frank, JH Duyn,
    Fast 3D functional magnetic resonance imaging at 1.5 T with spiral acquisition.
     Magn Reson Med 1996 36:620-6
  54. NF Ramsey, K Tallent, P van Gelderen, JA Frank, CTW Moonen, DR Weinberger
    Reproducibility of Human 3D fMRI Brain Maps Acquired During a Motor Task,
    Human Brain Mapping 1996 4: 113-121.
  55. NF Ramsey, BS Kirkby, P Van Gelderen, KF Berman, JH Duyn, JA Frank, VS Mattay, JD Van Horn, G Esposito, CTW Moonen, DR Weinberger,
    Functional mapping of human sensorimotor cortex with 3D BOLD fMRI correlates highly with H2(15)O PET rCBF.
     J Cereb Blood Flow Metab 1996 16:755-64
  56. JA de Zwart, P van Gelderen, DJ Kelly, CTW Moonen,
    Fast magnetic-resonance temperature imaging.
     J Magn Reson B 1996 112:86-90
  57. G Liu, P van Gelderen, J Duyn, CTW Moonen,
    Single-shot diffusion MRI of human brain on a conventional clinical instrument.
     Magn Reson Med 1996 35:671-7
  58. P van Gelderen, NF Ramsey, G Liu, JH Duyn, JA Frank, DR Weinberger, CTW Moonen,
    Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner.
     Proc Natl Acad Sci U S A 1995 92:6906-10
  59. CTW Moonen, P van Gelderen, NF Ramsey, G Liu, JH Duyn, JA Frank, DR Weinberger,
    PRESTO, a Rapid 3D Approach for Functional MRI of Human Brain,
    Proceedings Symposium on fuctional MRI, Rome, Oct. 26-28, 1995, (Pavone, Rossi, eds.), Springer Verlag, 1996.
  60. P van Gelderen, JH Duyn, CTW Moonen,
    Analytical solution for phase modulation in BURST imaging with optimum sensitivity.
     J Magn Reson B 1995 107:78-82
  61. P van Gelderen, CTW Moonen, JH Duyn,
    Susceptibility insensitive single shot MRI combining BURST and multiple spin echoes.
     Magn Reson Med 1995 33:439-42
  62. VS Mattay, DR Weinberger, FA Barrios, GS Sobering, KJ Kotrla, P van Gelderen, JH Duyn, RH Sexton, CTW Moonen, JA Frank,
    Brain mapping with functional MR imaging: comparison of gradient-echo--based exogenous and endogenous contrast techniques.
     Radiology 1995 194:687-91
  63. P van Gelderen, JH Duyn, G Liu, CTW Moonen
    T2* weighting for BOLD-type functional MRI of the human brain,
    Proc. Indian Acad. Sci. 1994 106: 1617-1624.
  64. JH Duyn, P van Gelderen, P Barker, JA Frank, VS Mattay, CTW Moonen,
    3D bolus tracking with frequency-shifted BURST MRI.
     J Comput Assist Tomogr 1994 18:680-7
  65. JH Duyn, P van Gelderen, G Liu, CTW Moonen,
    Fast volume scanning with frequency-shifted BURST MRI.
     Magn Reson Med 1994 32:429-32
  66. P van Gelderen, D DesPres, PC van Zijl, CTW Moonen,
    Evaluation of restricted diffusion in cylinders. Phosphocreatine in rabbit leg muscle.
     J Magn Reson B 1994 103:255-60
  67. P van Gelderen, MH de Vleeschouwer, D DesPres, J Pekar, PC van Zijl, CTW Moonen,
    Water diffusion and acute stroke.
     Magn Reson Med 1994 31:154-63
  68. PC van Zijl, AS Chesnick, D DesPres, CTW Moonen, J Ruiz-Cabello, P van Gelderen,
    In vivo proton spectroscopy and spectroscopic imaging of [1-13C]-glucose and its metabolic products.
     Magn Reson Med 1993 30:544-51
  69. P van Gelderen, A Olson, CTW Moonen,
    A single-shot diffusion experiment,
     J Magn. Reson. A, 103, 1993, 105-108.
  70. G Liu, G Sobering, AW Olson, P van Gelderen, CTW Moonen,
    Fast echo-shifted gradient-recalled MRI: combining a short repetition time with variable T2* weighting.
     Magn Reson Med 1993 30:68-75
  71. JW van der Veen, P van Gelderen, JH Creyghton, WM Bovee,
    Diffusion in red blood cell suspensions: separation of the intracellular and extracellular NMR sodium signal.
     Magn Reson Med 1993 29:571-4
  72. J Ruiz-Cabello, GW Vuister, CTW Moonen, P van Gelderen, JS Cohen, PCM van Zijl
    Gradient-enhanced hetronuclear correlation spectroscopy. Theory, experimental aspects
     J Mag. Res. 1992 100: 282-302.
  73. CTW Moonen, P van Gelderen, GW Vuister, PCM van Zijl
    Gradient-Enhanced Exchange Spectroscopy,
     J Mag. Res. 1992 97: 419-425.
  74. CTW Moonen, G Liu, P van Gelderen, G Sobering,
    A fast gradient-recalled MRI technique with increased sensitivity to dynamic susceptibility effects.
     Magn Reson Med 1992 26:184-9
  75. J Pekar, L Ligeti, Z Ruttner, RC Lyon, TM Sinnwell, P van Gelderen, D Fiat, CTW Moonen, AC McLaughlin,
    In vivo measurement of cerebral oxygen consumption and blood flow using 17O magnetic resonance imaging.
     Magn Reson Med 1991 21:313-9
  76. CTW Moonen, J Pekar, MH de Vleeschouwer, P van Gelderen, PC van Zijl, D DesPres,
    Restricted and anisotropic displacement of water in healthy cat brain and in stroke studied by NMR diffusion imaging.
     Magn Reson Med 1991 19:327-32

 
   

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